Coronary Artery Bypass Surgery. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group: patients receive 10 mg Melatonin every night two weeks before the operation. Intervention 2: Control group: patients in the placebo group received placebo every ni
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients who are candidate for elective CABG age between 40-75 years old ASA class <III pump time less than 90 min; graft number between 2 to 6
Exclusion criteria
Exclusion criteria: pregnancy local or systemic infection hyper sensitivity redo surgery surgery during last 6 months collagen vascular disease immunosuppressive disease heart failure with ejection fraction less than 35% recent cardiovascular event renal failure alcohol abuser simultaneously valvular heart surgery uncontrolled HTN liver failure breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of interleukin 6 and interleukin 9. Timepoint: two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahtab Setoodeh
Shiraz University of Medical Sciences
Outcome results
None listed