Coronary Artery Bypass Surgery. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group: Intervention group: patients receive 10 mg Melatonin every night two weeks before the operation. Intervention 2: Control group: patients in the placebo group receiv
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: En Patients who are candidate for elective CABG Age between 40-75 years old ASA class <III; pump time less than 90 min; graft number between 2 to 6. Pump time less than 90 min; graft number between 2 to 6. Graft number between 2 to 6.
Exclusion criteria
Exclusion criteria: pregnancy and breast feeding local or systemic infection hyper sensitivity redo surgery surgery during last 6 months collagen vascular disease immunosuppressive disease heart failure with ejection fraction less than 35% recent cardiovascular event uncontrolled HTN renal failure liver failure alcohol abuser malignancy simultaneously valvular heart surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of interleukin 13. Timepoint: two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples.;Serum level of interleukin 22. Timepoint: two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhad Izadpanah
Shiraz University of Medical Sciences
Outcome results
None listed