Evaluation and comparison of the preconditioning effect of Remifentanil Vs. Fentanyl on prevalence of early graft dysfunction among patients with liver transplant

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141009019470N70

Enrollment

100

Registered

2018-02-19

Start date

2018-02-15

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

organ transplant. Surgical operation with transplant of whole organ

Interventions

Intervention 1: Intervention group: In the remifentanil group, patients received intravenous propofol infusion with doses of 100-150 µg/kg/min as a base of maintenance of anaesthesia and remifentanil

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: aged 18 to 65 years old patients who are candidate for liver transplant

Exclusion criteria

Exclusion criteria: allergy to propofol soy beans and egg donors with cardio-pulmonary arrest or hemodynamic instability with high doses of inotropes (infusion nor epinephrine above µg/min) cold ischemia time more than 12 hours. history of hepatopulmonary syndrome history of portopulmonary hypertension renal insufficiency (Cr > 1.5 mg/L)

Design outcomes

Primary

Measure	Time frame
Aspartate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (Alkp), prothrombin time (PT), partial thrombin time (PTT) international normalized ratio (INR). Timepoint: from day 1 to 7 post-operation. Method of measurement: blood sample.	—

Secondary

Measure	Time frame
Blood urea nitrogen (BUN). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Duration of hospital and ICU stay. Timepoint: From day 1 to the day of dicharge. Method of measurement: Observation.;Metabolic acidosis (PH, base excess (BE). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Creatinine (Cr). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Duration of mechanical ventilation. Timepoint: From day 1 to 7 post-operation. Method of measurement: Observation.;Extubation time post- operation. Timepoint: From day 1 to 7 post-operation. Method of measurement: Observation.;Cold and warm ischemia time. Timepoint: Intra-operative. Method of measurement: Observation.;Amount of received blood products during the operation. Timepoint: Intra-operative. Method of measurement: Observation.	—

Measure

Time frame

Blood urea nitrogen (BUN). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Duration of hospital and ICU stay. Timepoint: From day 1 to the day of dicharge. Method of measurement: Observation.;Metabolic acidosis (PH, base excess (BE). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Creatinine (Cr). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Duration of mechanical ventilation. Timepoint: From day 1 to 7 post-operation. Method of measurement: Observation.;Extubation time post- operation. Timepoint: From day 1 to 7 post-operation. Method of measurement: Observation.;Cold and warm ischemia time. Timepoint: Intra-operative. Method of measurement: Observation.;Amount of received blood products during the operation. Timepoint: Intra-operative. Method of measurement: Observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanaz Jowkar

Shiraz University of Medical Sciences

masihifarzaneh@yahoo.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026