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Epidermal Growth Factor adjuvant therapy for psoriasis

Evaluation of topical adjuvant treatment of psoriasis with recombinant Epidermal Growth Factor to control the e-regulation of the Epidermal Growth Factor Receptor (EGFR): clinical trial phase 2

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141007019432N8
Enrollment
21
Registered
2022-03-12
Start date
2022-04-21
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psoriasis. Psoriasis

Interventions

Intervention 1: Intervention group: The intervention group will receive a topical cream containing 5% recombinant epidermal growth factor, twice a day for a month. Intervention 2: Control group: the g

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Informed consent Mild to moderate psoriasis (all types) with active plaques on both body sides accessible for self product application Age 18-60 years

Exclusion criteria

Exclusion criteria: Systemic psoriasis treatment 3 months prior and during the study Local psoriasis treatment on the investigational sites in the last 30 days or during the study Known hypersensitivity or allergy to the EGF containing product and/or to Vaseline/10% salicylic acid History of malignant disease Other clinically relevant concomitant disease state Participation in another investigational drug study in the last 30 days

Design outcomes

Primary

MeasureTime frame
Measure of Psoriasis Area and Severity Index (PASI). Timepoint: before intervention and 1. Method of measurement: Psoriasis Area and Severity Index (PASI) based on the standard.

Secondary

MeasureTime frame
Skin quality. Timepoint: Before intervention and 1. Method of measurement: Ultrasound skin imaging.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadamir Amirkhani

Tehran University of Medical Sciences

amirkhani@health.gov.ir+98 21 2220 1710

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026