Aging and preorbital wrinkle.
Conditions
Interventions
Intervention 1: Intervention group:In this study, 15 patients with the same conditions of entry are matched with t skin and stem cells research center . wrinkles around the eye on one of the side face
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 50 Years
Inclusion criteria
Inclusion criteria: Aged between 35 to 50 years old. Having a healthy face for dermatological, anatomical and sympathetic diseases Being in the wrinkle grade 2 and 3 according to the Lemperle 4 table Having psychological and social health (based on self-expression) Having knowledge And have enough time to cooperate until the end of the plan
Exclusion criteria
Exclusion criteria: Without any restorative intervention in the form of sub-sission , botox, filler, lift and surgery and etc, Having plenty of wrinkles in different areas of the skin Mental and social obsessive-compulsive disorder (based on self-declaration) history of related skin diseases, autoimmune, allergies or inflammation near the site history of prematurity cardiovascular, respiratory, diabetes, wound healing, moderate to high anemia, and other diseases that affect the process of rejuvenation history of systemic diseases history of oral and maxillofacial infections positive screening tests HIV1.2Ab, HBsAg, HbcAb, HCVAb,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of liposomal epidermal growth factor production on the surface and depth of preorbital wrinkle. Timepoint: before intervention and 3 months after using. Method of measurement: The statistical population is according to the degree of wrinkles 2 and 3 in thecase of women aged between 35 and 50 years that are selected by written consent. In this study, viscosity of the skin with visioface (D1000 ck Cologne, Germany), the level and degree of wrinkle with the set (LL 650 CK Germany), the thickness and density of the skin, the dermal and epidermal with ultrasound skin scanner, DUB-TPA EOTECH, Marcoussis, France), Multiprobe , elasticity with Adapter Cutometer (Cologne, Germany) ,skin water levels by chronometer devices are examined before and after using cream for 3 months and the numbers will be compared. All statistical analyses will be done in SPSS software. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of liposomal epidermal growth factor production on moisture ,elasticity and dermal -epidermal thickness,. Timepoint: before intervention and 3 months after using. Method of measurement: The statistical population is according to the degree of wrinkles 2 and 3 in thecase of women aged between 35 and 50 years that are selected by written consent. In this study, viscosity of the skin with visioface (D1000 ck Cologne, Germany), the level and degree of wrinkle with the set (LL 650 CK Germany), the thickness and density of the skin, the dermal and epidermal with ultrasound skin scanner, DUB-TPA EOTECH, Marcoussis, France), Multiprobe , elasticity with Adapter Cutometer (Cologne, Germany) ,skin water levels by chronometer devices are examined before and after using cream for 3 months and the numbers will be compared. All statistical analyses will be done in SPSS software. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammadamir Amirkhani
Tehran University of Medical Sciences
Outcome results
None listed