Atrophic disorders of skin (aging). Atrophic disorder of skin
Conditions
Interventions
Firstly biometric parameters of candidate face before intervention would be measured and then about 0.5 cm2 of skin biopsy from behind the ear would be taken via puncher. Fibroblast cells isolated and
Sponsors
Tehran University of Medical Sciences
Sinacell Corporation
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: age about 35 to 65 years old Having no anatomic disorder in face Wrinkle type between grade 2 to 4 Normal mental health Ability to comply with the study requirements Provide written informed consent Negative pregnancy test (Females)
Exclusion criteria
Exclusion criteria: being smokers or drinkers any past skin intervention in face Having many wrinkles on the face type of 1 or 5 of wrinkle scoring having a mental disorder Previous treatment with the filler's product History of active autoimmune disease or organ transplantation Diagnosis of cancer, unless successfully treated or in remission (basal cell carcinoma is excluded) Active or chronic skin disease Known genetic disorders affecting fibroblasts or collagen Active systemic infection Requires chronic antibiotic or steroidal therapy Known allergic reactions to agents used in preparation of treatment Excessive exposure to sun without adequate sun protection Use of systemic agents that increase bleeding or clotting, or disorders equated with these effects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantity of facial wrinkle - Extension. Timepoint: Months: 1, 3 and 6 after cell therapy. Method of measurement: Biometry with visioface & skin sonography.;Quality of facial wrinkle - deep. Timepoint: Months: 1, 3 and 6 after cell therapy. Method of measurement: Biometry with visioface & skin sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Color. Timepoint: Months: 1, 3 and 6 after cell therapy. Method of measurement: Biometry with colorimeter.;Elastisity. Timepoint: Months: 1, 3 and 6 after cell therapy. Method of measurement: MPA 9. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahsa Mollapour
Tehran University of Medical Sciences
Outcome results
None listed