schizophrenia. schizophrenia
Conditions
Interventions
Intervention 1: Tablets Risperidone (4-6 mg/day) combined with 40 mg/day simvastatin as intervention group for 8 weeks. Intervention 2: Tablet Risperidone (4-6 mg/day) combined with placebo as control
Treatment - Drugs
Placebo
Tablets Risperidone (4-6 mg/day) combined with 40 mg/day simvastatin as intervention group for 8 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria:1-Diagnosis of Schizophrenia based on DSM- 5 criteria;2- Minimum Score of 20 in negative subscale of Positive and Negative Scale(PANNS) 3- Age between 18-50; 4- chronic Schizophrenia- duration of the disorder more than 2 years; ; Exclusion Criteria:1-any other mental disorder on axis I; 2-Any serious medical or neurological problem; 3- IQ less than 70; 4- Substance dependence(except for nicotine and caffeine); 5-receiving ECT during the last 14 days,6-Depression Score less than 12 in Hamilton depression scale
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 2-4-8 after beginig of treatment. Method of measurement: Positive and Negative Syndrome Scale (PANSS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Extrapyramidal side effects. Timepoint: Baseline and weeks 2-4-6-8 after beginig of treatment. Method of measurement: by Extrapyramidal Symptoms Rating Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed