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Comparison of the effect of dexmedetomidine-ketamine with propofol-ketamine on pain and agitation in patients

Comparison of the effect of dexmedetomidine-ketamine with propofol-ketamine on pain and agitation in patients undergoing minor orthopedic surgeries; A double-blind randomized clinical trial.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141001019359N20
Enrollment
90
Registered
2026-05-13
Start date
2026-01-11
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain and sedation. Acute pain, not elsewhere classified

Interventions

Intervention 1: Control group: Patients in this group will receive intravenous ketamine (darman-yab daru) at a dose of 1 mg/kg over 10 minutes before the start of surgery. Intervention 2: Intervention

Sponsors

Bojnourd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Be a candidate for minor orthopedic surgery The American Society of Anesthesiologists physical status I-II No history of drug addiction. Participants with no known hypersensitivity to the intervention drugs

Exclusion criteria

Exclusion criteria: participants who had a history of severe cardiac disease participants who had a history of severe renal disease participants who had a history of severe systemic disease

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Before the intervention, 5-minute intervals during the intervention, and after the intervention. Method of measurement: Visual Analog Score (VAS).;Sedation. Timepoint: Before the intervention, 5-minute intervals during the intervention, and after the intervention. Method of measurement: Ramsay Scale.

Secondary

MeasureTime frame
Heart Rate. Timepoint: Before the intervention, 5-minute intervals during the intervention, and after the intervention. Method of measurement: Cardiac and respiratory monitoring.;Mean arterial pressure (MAP). Timepoint: Before the intervention, 5-minute intervals during the intervention, and after the intervention. Method of measurement: Cardiac and respiratory monitoring.;Arterial oxygen saturation (SpO2). Timepoint: Before the intervention, 5-minute intervals during the intervention, and after the intervention. Method of measurement: Cardiac and respiratory monitoring.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Zeraati

Bojnourd University of Medical Sciences

zeraatih@gmail.com+98 58 3151 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026