Comparison of the efficacy of dexmedetomidine with propofol on agitation and pain during dressing in burn patients undergoing sedation with ketamine

Comparison of the efficacy of dexmedetomidine with propofol on agitation and pain during dressing in burn patients undergoing sedation with ketamine, a double blinded randomized clinical trial.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141001019359N19

Enrollment

Registered

2025-12-02

Start date

2025-12-06

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain and sedation during burn dressing changes. Acute pain, not elsewhere classified

Interventions

Intervention 1: Intervention group:Patients in this group will receive ketamine at a sedative dose of 1 mg/kg intravenously over a period of 4 minutes Before intervention. Intervention 2: Intervention

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Participants with no known hypersensitivity to the intervention drugs. ASA physical status I-II No history of drug addiction

Exclusion criteria

Exclusion criteria: Participants with a history of severe cardiac, renal, psychiatric, or systemic disease

Design outcomes

Primary

Measure	Time frame
Pain assessment during burn dressing change. Timepoint: during burn dressing change. Method of measurement: Visual Analog Score (VAS).;Assessment of sedation during burn dressing changes. Timepoint: during burn dressing change. Method of measurement: Richmond Agitation Sedation Scale (RASS) Scale.	—

Secondary

Measure	Time frame
Evaluation of hemodynamic variables. Timepoint: During changing a burn dressing. Method of measurement: Researcher-made questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Zeraati

Bojnourd University of Medical Sciences

zeraatih@gmail.com+98 58 3151 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026