Comparison of the Effects of Dexmedetomidine–Ketamine versus Propofol–Ketamine Combination on Agitation and Pain

Comparison of the Effects of Dexmedetomidine–Ketamine versus Propofol–Ketamine Combination on Agitation and Pain During Bronchoscopy: A Double-Blind Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141001019359N18

Enrollment

Registered

2025-11-05

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain during bronchoscopy.

Interventions

Intervention 1: Intervention Group: Patients in this group will receive ketamine at a sedative dose of 1 mg/kg intravenously over a period of 4 minutes Before bronchoscopy. Intervention 2: Ketopropofo

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Participants with no known hypersensitivity to the intervention drugs. ASA physical status I-II No history of drug addiction

Exclusion criteria

Exclusion criteria: Participants with a history of severe cardiac, renal, psychiatric, or systemic disease

Design outcomes

Primary

Measure	Time frame
Assessment of Pain During Bronchoscopy. Timepoint: During Bronchoscopy. Method of measurement: Visual Analog Score (VAS).;Level of Sedation. Timepoint: During Bronchoscopy. Method of measurement: RASS Scale.	—

Secondary

Measure	Time frame
Evaluation of Complications. Timepoint: During Bronchoscopy. Method of measurement: Researcher-Designed Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Zeraati

Bojnourd University of Medical Sciences

zeraatih@gmail.com+98 58 3151 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026