Simultaneous effect of three dexmedetomidine administration methods on hemodynamic responses following laryngoscopy

Comparison between three methods of administration Dexmedetomidine on hemodynamic responses to Laryngoscopy and intubation; A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141001019359N15

Enrollment

120

Registered

2022-11-04

Start date

2022-11-20

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic variables. Other complications of anesthesia

Interventions

Intervention 1: Intervention group DIV: In this group, Patients will receive Dexmedetomidine intravenously at a dose of 0.5µ/kg by infusion pump within 40 minutes before induction of anesthesia. Inter

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: The Patient must be between 20 and 60 years old ASA physical status I-II The Patient must not have any intranasal lesions The patient must not have cardiovascular problems The patient must not have asthma or respiratory illness

Exclusion criteria

Exclusion criteria: Patients who are addictive or have drug abuse Patients with an unanticipated difficult airway.

Design outcomes

Primary

Measure	Time frame
Changes in hemodynamic parameters during intubation. Timepoint: After induction of anesthesia, in the first 5 minutes after intubation, every 1 minute after induction and on minutes 7 and 10. Method of measurement: Using the monitoring device.	—

Secondary

Measure	Time frame
Hemodynamic responses during skin incision. Timepoint: Skin incision time. Method of measurement: Patients' response to skin incision will be recorded as yes/no (no if less than 20% changes in hemodynamic parameters and yes if more than 20% changes are observed in them).;Patient's sedation status. Timepoint: At the entering of the operating room and then 40 minutes after the interventions. Method of measurement: Ramsey's sedation scale.;Extubation time after reversal of neuromuscular relaxant. Timepoint: From the time of administration of Neostigmine to removal of the endotracheal tube. Method of measurement: chronometer.;Post-operative nausea and vomiting. Timepoint: 2 hours after the operation. Method of measurement: In the form of presence or absence.;Sore throat after operation. Timepoint: 2 hours after the operation. Method of measurement: In the form of presence or absence.	—

Measure

Time frame

Hemodynamic responses during skin incision. Timepoint: Skin incision time. Method of measurement: Patients' response to skin incision will be recorded as yes/no (no if less than 20% changes in hemodynamic parameters and yes if more than 20% changes are observed in them).;Patient's sedation status. Timepoint: At the entering of the operating room and then 40 minutes after the interventions. Method of measurement: Ramsey's sedation scale.;Extubation time after reversal of neuromuscular relaxant. Timepoint: From the time of administration of Neostigmine to removal of the endotracheal tube. Method of measurement: chronometer.;Post-operative nausea and vomiting. Timepoint: 2 hours after the operation. Method of measurement: In the form of presence or absence.;Sore throat after operation. Timepoint: 2 hours after the operation. Method of measurement: In the form of presence or absence.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Esmaeili

Bojnourd University of Medical Sciences

dresmaely8@gmail.com+98583151

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026