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Comparison of the effect of Dexmedetomidine with intravenous Paracetamol on Pain induced by Propofol

Comparison of the effect of Dexmedetomidine with intravenous Paracetamol on Pain induced by Propofol 4oc injection; A double-Blind Randomized Clinical Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141001019359N14
Enrollment
90
Registered
2022-09-28
Start date
2022-10-07
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain. Pain, not elsewhere classified

Interventions

Intervention 1: Intervention group A: Before induction of anesthesia, Dexmedetomidine (0.5 µg/kg) will be slowly injected for 5 minutes. Intervention 2: Intervention group B: Before induction of anest

Sponsors

Bojnourd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The patient must be alert The patient must be a candidate for surgery under general anesthesia The patient must not have coagulation problems The patient must not be allergic to Propofol or the other drugs in the study The patient must not have cardiovascular problems

Exclusion criteria

Exclusion criteria: Patients who are addictive or have drug abuse Patients with hepatic failure

Design outcomes

Primary

MeasureTime frame
Propofol injection pain. Timepoint: Measuring pain in a time interval of 5 to 10 seconds during Propofol injection. Method of measurement: Visual Analog Score (VAS) Form of pain and Numeric rating scale (NRS) For rating the pain.

Secondary

MeasureTime frame
Mean Arterial Pressure (MAP). Timepoint: Before Propofol injection, 5 seconds after Propofol injection, 30 seconds after Propofol injection. Method of measurement: Use of Monitoring device.;Heart Rate (HR). Timepoint: Before Propofol injection, 5 seconds after Propofol injection, 30 seconds after Propofol injection. Method of measurement: Use of monitoring device.;Length of recovery and return from anesthesia. Timepoint: From extubation until the patient regains consciousness. Method of measurement: Time observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Esmaeili

Bojnourd University of Medical Sciences

dresmaely8@gmail.com+98583151

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026