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Comparison of the effect of Intrathecal addition of Dexmedetomidine and Sufentanil to Bupivacaine in Patients Undergoing Knee Prosthesis

Comparison of the effect of Intrathecal addition of Dexmedetomidine and Sufentanil to Bupivacaine in Patients Undergoing Knee Prosthesis under Spinal Anesthesia: a Double-blind Randomized Clinical Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141001019359N12
Enrollment
90
Registered
2022-04-08
Start date
2022-05-22
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain. Pain, not elsewhere classified

Interventions

Intervention 1: Intervention group 1: In this group of patients to perform spinal anesthesia, anesthesiologist in combination with the main anesthetic drug (bupivacaine)
10 micrograms of dexmedetomidine will be injected into the intrathecal space. Intervention 2: Intervention group 2: In this group of patients to perform spinal anesthesia, anesthesiologist in combina
? micrograms of sufentanil will be injected into the intrathecal space. Intervention 3: Control group:In this group of patients, for spinal anesthesia, the anesthesiologist will inject only the main a

Sponsors

Bojnourd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Be vigilant Do not Have history of previous surgery, Do not Have history of taking anti-anxiety, analgesic and sedative drugs Do not Have history of allergies to drugs used in the study Do not have drug addiction. Age between 40 to 70 years

Exclusion criteria

Exclusion criteria: Patients undergoing general anesthesia for any reason after spinal anesthesia

Design outcomes

Primary

MeasureTime frame
Level of analgesia. Timepoint: After performing spinal anesthesia technique. Method of measurement: Pin Prink method.;Duration of analgesia. Timepoint: The patient's first request for an analgesic injection. Method of measurement: Researcher-made questionnaire.;Intensity of pain. Timepoint: The patient's first request for an analgesic injection. Method of measurement: visual analog scale.

Secondary

MeasureTime frame
Physiological parameters (blood pressure, heart rate, mean arterial pressure). Timepoint: After the spinal technique, for the first 15 minutes every 2 minutes and then every 4 minutes until the end of surgery. Method of measurement: Cardiac monitoring.;Drug side effects. Timepoint: End of surgery up to 24 hours later. Method of measurement: Researcher-made questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Zeraati

Bojnourd University of Medical Sciences

zeraatih@gmail.com+98 58 3229 1910

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026