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Effect of GnRH-a and OCP on the result of IVF in females with moderate and sever endomethriosis.

Comparative study on the pregnancy outcomes of IVF between GnRH-a and OCP in women with moderate and sever endomethriosis.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201409301556N64
Enrollment
Unknown
Registered
2014-10-11
Start date
2014-10-12
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endomethriosis. Noninflammatory disorders of female genital tract

Interventions

Intervention 1: Hundred infertile women with mod and sever endomethriosis according to the revised American Fertility Society classification were scheduled for IVF. In interventional group(50) the pa
Treatment - Drugs
Hundred infertile women with mod and sever endomethriosis according to the revised American Fertility Society classification were scheduled for IVF. In interventional group(50) the patients takes OC
Hundred infertile women with mod and sever endomethriosis according to the revised American Fertility Society classification were scheduled for IVF . In control group(50) the patients received a 3.
) and/or human menopausal gonadotropin . Human chorionic gonadotropin (hCG) was administered to trigger egg maturation when at least 1 follicle achieved a mean diameter of 17 mm. The patients were s

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Hundred infertile women with moderate and sever endomethriosis according to the revised American Fertility Society classification were scheduled for IVF. These patients were in line with: moderate and sever endometriosis; age less than 35 years old; FSH level below 10 U/L; 27>BMI>20. Exclusion criteria: minimal and mild endometriosis; potentialy poor responder; endocrine disorders.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Number of retrieved oocytes. Timepoint: Oocyte retrieval 34 to 36 hours after the hCG injection. Method of measurement: Base on microscopic finding.;Number of MII oocytes. Timepoint: MII oocytes after retrieval. Method of measurement: Base on microscopic finding.;Fertilization rate. Timepoint: Fertilization was assessed by pronuclei formation at 24 h after oocyte retrieval and by subsequent cleavage. Method of measurement: Base on microscopic finding.;Implantation rate. Timepoint: Implantation rate was defined as number of ultrasonographically visualized gestational sacs. Method of measurement: Ultrasonography.;The number of embryo transfer. Timepoint: Day 2 or day 3 embryos were transferred. Method of measurement: pationt's file.

Secondary

MeasureTime frame
Clinical pregnancy. Timepoint: Ongoing pregnancy was defined as a uterine pregnancy of more than 12 weeks' duration. Method of measurement: Ultrasonography.;Pregnancy rate per embryo transfer. Timepoint: pregnancy rate was defined as number of ultrasonographically visualized gestational sacs per number of embryos transferred. Method of measurement: ultrasonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahboobeh Mohammadi

Arash Hospital

mahaoo58@yahoo.com+98 21 7788 8753

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026