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The effect of oral Gabapentin premedication upon bleeding and hemodynamic changes due to direct laryngoscopy

Evaluating the effect of oral Gabapentin premedication upon bleeding and hemodynamic changes due to direct laryngoscopy and endotracheal intubation in patients candidate for septorinoplasty surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201409288677N3
Enrollment
100
Registered
2014-12-01
Start date
2014-11-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding. Other specified disorders of nose and nasal sinuses

Interventions

Intervention 1: Intervention 1) 900 mg (3×300 mg capsules) Gabapentin made by Iran Darou industries is taken single daily dose with 20 ml water, 2 hours before operation. Intervention 2: Intervention
Treatment - Drugs
Intervention 1) 900 mg (3×300 mg capsules) Gabapentin made by Iran Darou industries is taken single daily dose with 20 ml water, 2 hours before operation
Intervention 2) Three capsules looking exactly like Gabapentin capsule including placebo which is made by the same industry is taken by the patient 2 hours before surgery

Sponsors

Vice Chancellor for research of Guilan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 18 to 45 years old; American Society of Anesthesiologists (ASA) I,II; Candidate for Septorinoplasty Exclusion criteria: Drug Side effects; Patients refuse treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Heart Rate. Timepoint: Upon arrival to operating room,3 ,5 ,10 ,15 minutes after endotracheal intubatioin and 10 minutes after extubation. Method of measurement: Beats per minute (bpm) by Saadat monitoring system.;Systolic Blood Pressure. Timepoint: Upon arrival to operating room,3 ,5 ,10 ,15 minutes after endotracheal intubatioin and 10 minutes after extubation. Method of measurement: mmHg by Saadat monitoring system.;Amount of intra operative bleeding. Timepoint: At the end of the operation. Method of measurement: mL/According to the blood volume in the suction, by minus volume of physiological saline solution that added due to washing , plus 15 for each blood gaus.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarnoush Farzi

Guilan University of Medical Sciences

arcguilan1392@gmail.com+98 13 3331 0434

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026