schizophrenia. Schizophrenia, schizotypal and delusional disorder
Conditions
Interventions
Intervention 1: control group:placebo tablet that is similar to memantin in shape,size and color. starting with single dose 5mg per day then increase 5mg each week ,up to 10 mg at morning and 10 mg
Placebo
Treatment - Drugs
control group:placebo tablet that is similar to memantin in shape,size and color. starting with single dose 5mg per day then increase 5mg each week ,up to 10 mg at morning and 10 mg at night after
study group : memantine tab,starting with single dose 5mg per day then increase 5mg each week ,up to 10 mg at morning and 10 mg at night after 4 weeks and continue (10 mg BD)to12 weeks.
Sponsors
Vice chancellor for research of Isfahan Univercity of Medical science
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: inclusion criteria:age group 18-65 ; no mental retardation ;no pregnancy or milking ;diagnosis of schizophrenia for at least 2 years;treatment with atypical anti psychotic from 3 month ago;do not have ECT during 2 week ago Exclusion criteria:allergic to memantin;addiction or dependency to substance or drugs ;other psychiatric disorder or serious neurological deficit.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: at base line,each 4 weeks to 12weeks. Method of measurement: Quality Of Life scale of schizophrenia.;Global Function. Timepoint: at baseline,each 4 weeks to 12weeks. Method of measurement: Global Assesment Of Functioning.;Possitive and negative symptoms. Timepoint: at base line, each 4 weeks to12 weeks. Method of measurement: Possitive And Negative Symptom Scale.;Depression. Timepoint: at base line,each 4 weeks to12 weeks. Method of measurement: Calgary Depressive Scale for Schizophrenia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: during 12 weeks of study. Method of measurement: history of patient and his/her companion and physical exam. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadian Sichani Maryam
Isfahan University of Medical Sciences
Outcome results
None listed