ST elevation myocardial infarction. Acute myocardial infarction
Conditions
Interventions
Intervention 1: Intervention group: Normal saline (1-1.5 cc/kg from 6 hours before to 6 hours after coronary angioplasty) plus pentoxifylline (400 mg/tid from 24 h before to 24 h after coronary angiop
Treatment - Drugs
Intervention group: Normal saline (1-1.5 cc/kg from 6 hours before to 6 hours after coronary angioplasty) plus pentoxifylline (400 mg/tid from 24 h before to 24 h after coronary angioplasty).
Control group: Normal saline (1-1.5 cc/kg from six hours before to six hours after coronary angioplasty)
Sponsors
Vice chancellor for research of Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Consent to participate; ST elevation myocardial infarction (STMI) and age over 18 years. Exclusion criteria: serum creatinine more than 1.5 mg/dl, heart failure; history of end-stage renal failure or being on dialysis; use of N-acetyl cysteine, theophylline, aminoglycosides, and nonsteroidal anti-inflammatory drugs; intravenous contrast media administration within the past two days; pulmonary edema; multiple myeloma; and uncontrolled hypertension
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine levels. Timepoint: Before angioplasty, two days after angioplasty. Method of measurement: Blood test.;Contrast-induced nephropathy. Timepoint: 48 hours after angioplasty. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Ali Eshraghi
Mashhad University of Medical Sciences
Outcome results
None listed