Depression. Mild depressive episode ,Moderate depressive episode
Conditions
Interventions
Intervention 1: placebo tablet:(for control group)
it produced with the same color and size but without therapeutic effects ,
half tablet 3 ice a day for one month
and one tab 3 ice a day for 2 othe
Treatment - Drugs
placebo tablet:(for control group)
it produced with the same color and size but without therapeutic effects ,
half tablet 3 ice a day for one month
and one tab 3 ice a day for 2 other months
tot
Levodopa c tab 100/10
half tablet 3 ice a day for one month and one tab
3 ice a day for 2 other months
total study : 3 months
Sponsors
vice chancellor for research of Shiraz University of Medical Siences
Eligibility
Sex/Gender
All
Age
30 Years to 79 Years
Inclusion criteria
Inclusion criteria: Including criteria: The patients with idiopathic Parkinson disease should be between 30 to 79; Diagnosis is done according to bradykinesia, plus at least 2 other of postural unsteadiness and rigidity, resting tremor; patients who don't need symptomatic treatments; The patients should be in grade 3 or less according to yahr staging method; The patients should have clinical evidence of depression with grade 2 or more according to Depression question of UPDRS. Exclusion criteria: MMSE below 24; presence of suicidal idea; Use of Neuroleptic medications prior to first visit; History of Deep Brain Stimulation; Women of childbearing potential were excluded if they were pregnant, lactating, or not taking adequate contraception; Patients who received anti parkinson medication before study; Illiteracy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: first visit and 1month and 3 month after intervention. Method of measurement: Beck Depression test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor condition. Timepoint: at first visit ,1 month and 3 months after intervention. Method of measurement: UPDRS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRazie Rezaii
Neurology Department of Shiraz University of Medical School
Outcome results
None listed