Malignant neoplasms of digestive organs. Malignant neoplasm of rectum, anus and anal canal whose point of origin cannot be classified to any one of the categories C20-C21.2
Conditions
Interventions
Intervention 1: Patients will receive Lactobacillus acidophilus probiotic (capsules 500 mg, three times a day, before each meal) for at least 5 months before to two months after surgery and radiothera
Treatment - Drugs
Placebo
Patients will receive Lactobacillus acidophilus probiotic (capsules 500 mg, three times a day, before each meal) for at least 5 months before to two months after surgery and radiotherapy.
Patients will receive the placebo capsules of Lactobacillus acidophilus probiotic (three times a day, before each meal) for at least 5 months before to two months after surgery and radiotherapy.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Randomized; with obtaining written consent; rectum cancer in neoadjuvant stage. Exclusion criteria: Patients with kidney problems or liver problems; patients with serious heart problems; patients with metastatic lung and brain cancer; patients with intestinal obstruction; patients with GFR less 30; patients with immunodeficiency.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment. Timepoint: Before and after drug therapy, 5 months. Method of measurement: CT scan. | — |
Secondary
| Measure | Time frame |
|---|---|
| The assesment of quality of life. Timepoint: Befor and after of treatment, 5 months. Method of measurement: Questionnaires of FACT and CARES. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Mohammad Alizadeh
Tehran University of Medical Sciences
Outcome results
None listed