Diffuse axonal injury. Diffuse brain injury
Conditions
Interventions
Intervention 1: 8 micrograms of oral conjugated estrogen tablets per kg body weight, once a day until 3 days for the intervention group. Intervention 2: Not prescribed any medication for control group
Treatment - Drugs
8 micrograms of oral conjugated estrogen tablets per kg body weight, once a day until 3 days for the intervention group
Not prescribed any medication for control group.
Sponsors
Vice chanscellor for research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
14 Years to 69 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Men 15 to 70 years; Diffuse axonal injury diagnosis; GCS less than or equal to 8; Hospitalization in less than 8 hours of after trauma; Having informed consent to participate in the study; Lack of talent to thromboembolism. Exclusion criteria: Sex woman; Patients with refractory seizure; History of deep vein thrombosis or infection; Any history of head trauma; Any history of brain procedure; History of ischemic lesions and hemorrhagic stroke; People prone to pulmonary thromboembolism and deep vein thrombosis; (a) smoking; (b) a family history of deep vein thrombosis and pulmonary thromboembolism; (c) heart failure; (d) inflammatory bowel disease (ulcerative colitis); (e) a history of cancer; (f) hereditary disorders are prone to blood clots
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of consciousness. Timepoint: Admission time, discharge time and three months after discharge. Method of measurement: Glasgow coma scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKeyvan Aalizadeh, MD
Tabriz University of Medical Sciences
Outcome results
None listed