Condition 1: mania. Condition 2: bipolar disorder. bipolar affective disorder bipolar affective disorder
Conditions
Interventions
Intervention 1: Litium combined with Tabiet Aripiprazole(30 mg/day) as intervention group for 3 weeks. Intervention 2: Litium combined with Tablets Risperidon(6mg/day) as control group for 3weeks.
Treatment - Drugs
Litium combined with Tabiet Aripiprazole(30 mg/day) as intervention group for 3 weeks.
Litium combined with Tablets Risperidon(6mg/day) as control group for 3weeks.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: criteria: Age more than 18 years; Diagnosis of Bipolar disorder with psychotic symptom based on DSM-IV TR; Ongoing treatment with Litium as a mood stabilazor with seromic level between 0.8-1.2meq/L ; patient with YMRA>20.Exclusion criteria: Mental Retardation; Pregnancy or Breast Inclusion feeding;Any chronic medical problem; substance abuse; Any other psychiatric Disorder in Axis I OR II;Allergic to Aripiprazole and other Atypical Antipsychotic drug ;History of epileptic disorder; Delirium state.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of manic phase and psychotic symptom. Timepoint: Baseline and days 7-14-21 after beginig of treatment. Method of measurement: YMRS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Akatezia. Timepoint: days 2-4-7-10 after beginig of treatment then every weeks. Method of measurement: BARS.;Extrapyramidal. Timepoint: days 2-4-7-10 after beginig of treatment then every weeks. Method of measurement: AIMS.;Diskinesia. Timepoint: days 2-4-7-10 after beginig of treatment then every weeks. Method of measurement: SAS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Fatemeh Sheikhmoonesi
Mazandaran University of Medical Sciences
Outcome results
None listed