The efficacy of vitamin D and oral alendronate on Modic change

The efficacy of vitamin D and oral alendronate in patients with low back pain and modic changes who underwent lumbar fusion surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140915019185N2

Enrollment

Registered

2018-02-13

Start date

2015-09-01

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Lumbar discopathy. Condition 2: Spinal stenosis. Condition 3: Lumbar listesis.

Interventions

Intervention 1: Intervention group: fusion and alendronate: after fusion surgery,for 6 months, 70 mg of oral alendronate is given as a treatment every 2 weeks, with the necessary training. Interventio

Eligibility

Sex/Gender

Female

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Female patients with lumbar degenerative diseases undergoing pedicular screw fusion up to 4 level

Exclusion criteria

Exclusion criteria: Patients with infection,tumor,diabetes,history of previous surgery, rheumatoid diseases

Design outcomes

Primary

Measure	Time frame
Modic change. Timepoint: FIRS of study,6 month after study. Method of measurement: MRI.;Pain. Timepoint: 0,1,3,6. Method of measurement: Visual Analogue Scale.;Ability to do daily work. Timepoint: 0,1,3,6. Method of measurement: Oswestry Disability Index.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKaveh Haddadi

Sari University of Medical Sciences

k.haddadi@mazums.ac.ir+98 11 3335 7255

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026