A randomized double-blind placebo controlled clinical trial of the effect of Eutectic Mixture of Lidocaine and Prilocain (EMLA) anesthetic gel on pain during Probing in Patients With chronic Periodontitis

The effect of Eutectic Mixture of Lidocaine and Prilocain ( EMLA) anesthetic gel on pain during Probing in Patients With chronic Periodontists.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201409143720N4

Enrollment

Registered

2015-02-28

Start date

2013-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis. Periodontitis

Interventions

Intervention 1: Intervention group: EMLA gel 2.5% (Eutectic Mixture of Lidocain Prilocain)(Made by Pharmaceutical Laboratory of Hakim Co,Tehran- Iran . Intervention 2: "Control group":Placebo gel w

Treatment - Drugs

Placebo

Intervention group: EMLA gel 2.5% (Eutectic Mixture of Lidocain Prilocain)(Made by Pharmaceutical Laboratory of Hakim Co,Tehran- Iran .

"Control group":Placebo gel was prepared in the same manner but without the active drug in it(Made by Pharmaceutical Laboratory of Hakim Co,Tehran- Iran .

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria were: patients with chronic periodontists with PD =4 mm and CAL =3; patients needed to have a minimum of one incisors, one canine, one premolar, and one molar in two quadrants; patients with no periodontal therapy in the previous 6 months; and a signed informed consent form exclusion criteria: those requiring prophylactic antibiotics before periodontal probing; those suffering from any psychiatric disorders or with chronic pain problems; those with coagulation disorders or on anti coagulation therapy; female patients that were pregnant or lactating; patients with congenital or idiopathic met- hemoglobinemia or those receiving treatment with methemoglobin-inducing agents; those reporting allergies to dental anesthetics; those taking non-steroidal anti-inflammatory drugs in the 3 days before participation in the study; patients having acute periodontal pain, pulpits, abscesses,or other acute infections.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain during probing. Timepoint: before intervetion/30-45 seconds aftherintervention. Method of measurement: Visual analog pain with ruler (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Roya Shariatmadarahmadi

Islamic Azad University of Tehran-Dental Branch

dr.r.shariatmadari@gmail.com+98 21225645713

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026