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Effect of sodium bicarbonate on success of inferior alveolar anesthesia

Effect of supplementary infiltration injection of Sodium Bicarbonate on success rate of IANB of mandibular first molars with irreversible pulpitis: A Randomized, Clinical, Double-blind Study

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201409142541N4
Enrollment
100
Registered
2016-05-24
Start date
2016-02-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

irriversible pulpitis. Pulpitis: NOS acute chronic (hyperplastic)(ulcerative) irreversible reversible

Interventions

Intervention 1: infiltration injection involved 0.7 ml of distilled water and 0.3 ml of 2% lidocaine with 1.80000 epinephrine. Intervention 2: infiltration injection involved 0.7 ml of sodium bicarobo
Placebo
Treatment - Drugs
infiltration injection involved 0.7 ml of distilled water and 0.3 ml of 2% lidocaine with 1.80000 epinephrine
infiltration injection involved 0.7 ml of sodium bicarobonate and 0.3 ml of 2% lidocaine with 1.80000 epinephrine

Sponsors

Vice chancellor for research, Isfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:18 years of age and over; being in good health condition;having a mandibular first molar tooth with symptomatic irreversible pulpitis;not having periodontal problem; normal periapical radiographic appearance (other than a widened periodontal ligament); and normal periapical radiographic appearance (other than a widened periodontal ligament); no history of allergy Exclusion criteria: History of any systemic disorders, lactation, pregnancy, allergy to Local anesthesia, taking any medications that might influence anesthetic assessment, presence of periradicular radiolucency, swelling or having fistula near target tooth, active sites of pathosis in area of injections, or any problem that patient could not give informed consent; lack of lip numbness within 15 minutes after mandibular alveolar nerve block injection

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Before treatment and after initiating root canal therapy. Method of measurement: Heft-Parker visual analog scale (VAS).

Secondary

MeasureTime frame
Post pain. Timepoint: during procedure. Method of measurement: Heft-Parker visual analog scale recording of pain.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoud Saatchi

Isfahan University of Medical Sciences

saatchi@dnt.mui.ac.ir+98 31 3792 2822

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026