Treatment of ocular chemical burns with cellular fibrin membrane

Evaluation of the therapeutic effect of cellular fibrin membrane with autologous oral mucosal epithelial cells in the repair of chemical burns on the surface of the human eye - Phase 1 and 2 clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140911019125N9

Enrollment

Registered

2020-10-11

Start date

2020-10-22

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment of ocular chemical burns. Unspecified injury of eye and orbit

Interventions

Intervention group: In this study, after sampling from patients oral mucosa epithelial cells are extracted, fibrin membrane is prepared and coated with cells and then transplanted on eye surface of pa

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Adults aged between 18-40 years Patients with severe corneal epithelium defect Patients with favorable prognostic factors Patients with normal intraocular pressure Patients with normal light perception that shows the health of nerve of eye Patients with no retina disease Patient with no severe dry eye

Exclusion criteria

Exclusion criteria: Patients with severe systemic disorders Patients with mental disorders Pregnant women

Design outcomes

Primary

Measure	Time frame
Transparency of the cornea. Timepoint: Before intervention and 7 and 28 days after intervention. Method of measurement: Microscopic measurement.;Corneal smooth surface. Timepoint: Before intervention and 7 and 28 days after intervention. Method of measurement: Microscopic measurement.;Vascularization in cornea. Timepoint: Before intervention and 7 and 28 days after intervention. Method of measurement: Microscopic measurement.	—

Measure

Time frame

Transparency of the cornea. Timepoint: Before intervention and 7 and 28 days after intervention. Method of measurement: Microscopic measurement.;Corneal smooth surface. Timepoint: Before intervention and 7 and 28 days after intervention. Method of measurement: Microscopic measurement.;Vascularization in cornea. Timepoint: Before intervention and 7 and 28 days after intervention. Method of measurement: Microscopic measurement.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Farsinejad

Kerman University of Medical Sciences

afarsinejad@kmu.ac.ir+98 34 3132 5374

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026