effect of ovarian stimulation drugs on incidance of unruptured follicle

Evaluation of effect of ovarian stimulation protocol on incidance of luteinized unruptured follicle syndrome in infertile women undergoing induction ovulation and intrauterine insemination

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014091019113N1

Enrollment

180

Registered

2014-09-29

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: luteinized unruptured follicle. Condition 2: luteinized unruptured follicle. Female infertility associated with anovulation Female infertility, unspecified

Interventions

Intervention 1: Tab clomiphene citrate 100mg/d orally on 3-7 days of cycle in group1 Amp HMG 75IU/d IM from 8 day of cycle in group1 Amp HCG 10000IU IM when follicular diameter >>18mm in group1. In

Treatment - Drugs

Tab clomiphene citrate 100mg/d orally on 3-7 days of cycle in group1 Amp HMG 75IU/d IM from 8 day of cycle in group1 Amp HCG 10000IU IM when follicular diameter >>18mm in group1

Tab letrozole 5mg/d orally on 3-7 days of cycle in group 2 Amp HMG 75IU/d IM from 8 day of cycle in group 2 Amp HCG 10000IU IM when follicular diameter >>18mm in group2

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1-infertile women 18-35years old candidate for IUI 2-infertility causes:pco,unexplained infertility,male factor Exclusion criteria: 1-hyper prolactinemia,hypo and hyperthyroidism,ovarian cyst,NSAID users,uterus and tubal malfprmation 2-OHSS

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Luteinized unruptured follicle. Timepoint: 5-6 days after IUI. Method of measurement: sonography+ serum progesterone( ng/ml).	—

Secondary

Measure	Time frame
Follicular size. Timepoint: every other day from 10 day of cycle. Method of measurement: vaginal sonography.;Serum progesterone. Timepoint: 5-6 days after IUI. Method of measurement: blood test.;Ovulation. Timepoint: before and 5-6 days after IUI,. Method of measurement: vaginal sonography.;Pregnancy. Timepoint: 14days after IUI. Method of measurement: ßhcg blood test.;FSH. Timepoint: 2-3 day of cycle before included in stydy. Method of measurement: blood test.;Infertility cause. Timepoint: before included in study. Method of measurement: clinician judgement.;Endometrial thickness. Timepoint: every other day from 10 day of cycle. Method of measurement: vaginal sonography.;LH. Timepoint: 2-3day of cycle before included in study. Method of measurement: blood test.	—

Measure

Time frame

Follicular size. Timepoint: every other day from 10 day of cycle. Method of measurement: vaginal sonography.;Serum progesterone. Timepoint: 5-6 days after IUI. Method of measurement: blood test.;Ovulation. Timepoint: before and 5-6 days after IUI,. Method of measurement: vaginal sonography.;Pregnancy. Timepoint: 14days after IUI. Method of measurement: ßhcg blood test.;FSH. Timepoint: 2-3 day of cycle before included in stydy. Method of measurement: blood test.;Infertility cause. Timepoint: before included in study. Method of measurement: clinician judgement.;Endometrial thickness. Timepoint: every other day from 10 day of cycle. Method of measurement: vaginal sonography.;LH. Timepoint: 2-3day of cycle before included in study. Method of measurement: blood test.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Mansooreh Pejmanmanesh

IVF ward, Mirza Koochakkhan Hospital, Tehran University Of Medical Sciences

hosp_mirza@tums.Ac.Ir+98 21 8897 7614

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026