Acute Post Operative Renal Failure. Acute Renal Failure, Unspecified
Conditions
Interventions
Intervention 1: Intervention group1: Infusion of one liter of normal saline that will contain ascorbic acid (500 mg) during first two hours of anesthesia. Intervention 2: Intervention group 2: Infusio
Treatment - Drugs
Placebo
Intervention group1: Infusion of one liter of normal saline that will contain ascorbic acid (500 mg) during first two hours of anesthesia
Intervention group 2: Infusion of one liter of normal saline that will contain 75 ml of sodium bicarbonate 8.4% during first two hours of anesthesia
Placebo group: Infusion of one liter of pour normal saline during first two hours of anesthesia
Sponsors
Vice Chancellor for Research of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients above 18 years old who are candidate for elective cardiac surgery Exclusion Criteria: Urgent Surgery; Plasma creatinine concentration above 2 mg/dl; GFR lower than 50 ml/min; Insulin depended diabetes mellitus; Radio contrast exposure during last weak; left ventricle ejection fraction below 30%
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute renal failure. Timepoint: At second and fifth postoperative days. Method of measurement: Monitoring the increase in plasma creatinine more than 0.5mg/dl or decrease in GFR more than 25 percent up to fifth postoperative day comparing to preoperative values. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma Creatinine Concentration and Glomerular Filtration Rate. Timepoint: At Preoperative, Second and Fifth Post Operative Days. Method of measurement: Plasma Creatinine Concentration and Glomerular Filtration Rate measurement. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHassan Soleiman Pour
Medicine faculty, Tabriz University of Medical Sciences
Outcome results
None listed