The effect of vitamin D plus iron vs. vitamin D on bone health and inflammation in women

The effects of vitamin D or iron-vitamin supplementation on bone metabolism and inflammation in 18-40-year women

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201409082365N9

Enrollment

Registered

2014-10-27

Start date

2014-10-11

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Association between iron supplementation and vitamin D or vitamin D alone on bone metabolism and inflammation in women.

Interventions

Intervention 1: Intervention group participants will be prescribed two tablets (one 1000 international unit vitamin D plus one 27 mg elemental iron every day). They will instructed to take the tablets

Treatment - Drugs

Placebo

Intervention group participants will be prescribed two tablets (one 1000 international unit vitamin D plus one 27 mg elemental iron every day). They will instructed to take the tablets separately.

Control group participants will be prescribed two tablets (one 1000 international unit vitamin D plus one placebo every day). They will instructed to take the tablets separately.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Healthy; Non-smoker; Non-pregnant; Non-lactating; Body mass index: 18.5-29.9 kg/m2; Ferritin less than 30 ng/ml; Hemoglobin less than 12 g/dl; 25 hydroxy vitamin D less than 30 ng/ml. Exclusion criteria: Amenorrhea; Menopause; Minor Thalasemia; Hemochromatosis; Inflammatory bowel diseases; Crohn's disease; Gastric ulcer; Celiac disease; Gastrointestinal bleeding diseases; Renal diseases; Blood donation during past 3 months; Iron or Vitamin D supplement use during past 3 months.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
25 hydroxy vitamin D. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.	—

Secondary

Measure	Time frame
Hematocrit. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Mean Cell Vollum. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Hemoglobin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Serum iron. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Ferritin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Transferrin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Transferrin saturation. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Total Iron Binding Capacity. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Alkaline phosphatase. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Parathyroid hormone. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;C-terminal telopetide x. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Osteocalcin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Highly-sensitive C Reactive Protein. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Tumor Necrosis Factor Alpha. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Interleukin 6. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Total Antioxidant Capacity. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Malodialdehyde. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Lipid profile. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Fasting Blood Sugar. Timepoint: At baseline and the end of the study. Method of measurement: Blood sa	—

Measure

Time frame

Hematocrit. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Mean Cell Vollum. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Hemoglobin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Serum iron. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Ferritin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Transferrin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Transferrin saturation. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Total Iron Binding Capacity. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Alkaline phosphatase. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Parathyroid hormone. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;C-terminal telopetide x. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Osteocalcin. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Highly-sensitive C Reactive Protein. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Tumor Necrosis Factor Alpha. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Interleukin 6. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Total Antioxidant Capacity. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Malodialdehyde. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Lipid profile. Timepoint: At baseline and the end of the study. Method of measurement: Blood sample.;Fasting Blood Sugar. Timepoint: At baseline and the end of the study. Method of measurement: Blood sa

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammadreza Vafa

Nutrition and health group

rezavafa@yahoo.com+218 6704734

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 25, 2026