patent ductus arteriosus. Congenital malformations of great arteries
Conditions
Interventions
Intervention 1: Intervention group: Administration of 15mg/kg oral acetaminophen every 6 hours for 48 hours during first 24 hours after birth. Intervention 2: Control group: No intervention.
Treatment - Drugs
Intervention group: Administration of 15mg/kg oral acetaminophen every 6 hours for 48 hours during first 24 hours after birth
Control group: No intervention
Sponsors
Vice Chancellor for research of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
No minimum to 6 Days
Inclusion criteria
Inclusion criteria: Inclusion criteria: Premature neonates born at or before 32 weeks of gestation with birth weight less than or equal to 1500 grams admitted in neonatal intensive care unit of Vali-e-Asr Hospital in 2012; parental consent for participating in this study. Exclusion criteria: Newborns with congenital heart defects that patency of ductus arteriosus is vital for them such as pulmonary atresia; congenital major anomalies or chromosomal abnormalities; maternal consumption of none steroidal anti-inflammatory drugs during pregnancy; newborns with hydrops fetalis or persistent pulmonary hypertension of the newborn; apgar score less than 5 at fifth minute after birth; appearance of patent of dutus arteriosus symptoms and requirement for treatment with Ibuprofen at any time; having vomiting or hematemesis during first 3 days after birth; neonates with glucose-6-phosphate dehydrogenase deficiency based on blood exam at beginning of neonatal admission
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left Atrial to Aortic Ratio. Timepoint: 4-5 day of life. Method of measurement: Echocardiography.;Internal Ductal Diameter. Timepoint: 4-5 day of life. Method of measurement: Echocardiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Mohamad Reza Zarkesh
Tehran University of Medical Sciences
Outcome results
None listed