modafinil in treatment of crystal dependency

A clinical trial on the effect of modafinil in treatment of amphetamine and methamphetamine dependent patients.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014090219009N1

Enrollment

Registered

2015-11-01

Start date

2015-04-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amphetamine-Methamphetamine Dependency. Mental and behavioral disorders due to use of other stimulants, dependence syndrome

Interventions

Intervention 1: Two hundred milligrams of modafinil manufactured in Tolid Daroo Factory © taking orally per day for 12 weeks. Intervention 2: Placebo made in the Pharmacology college of Zabol medical

Treatment - Drugs

Placebo

Two hundred milligrams of modafinil manufactured in Tolid Daroo Factory © taking orally per day for 12 weeks.

Placebo made in the Pharmacology college of Zabol medical university of medical sciences taking orally per day for 12 weeks.

Eligibility

Sex/Gender

Male

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:male gender ;eighteen to sixty five years old ;Methamphetamine dependency approved by DMSIV-TR criteria ; Positive urine test for amphetamine and methamphetamine ; Having no contraindication for the use of modafinil Exclusion criteria: consuming different kind of drugs except for nicotine and methadone ; No history of psychiatric disorders ; Having medical conditions that may interfere with using modafinil ; Having suicidal thoughts and aggression ;. Participating in another study simultaneously ; Quitting the current study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Measure of craving. Timepoint: At the onset of the study and then weekly. Method of measurement: visual analogue of craving score.;Measuring the severity of dependency. Timepoint: At the onset of the study and then weeks 6th and 12th. Method of measurement: Dependency severity index.;Measuring the severity of depression. Timepoint: At the onset of the study and then weeks 6th and 12th. Method of measurement: Beck’s Depression Inventory.;Measuring the aggression severity. Timepoint: At the onset of the study and then weeks 6th and 12th. Method of measurement: Aggressive questionnaire (AGQ).	—

Measure

Time frame

Measure of craving. Timepoint: At the onset of the study and then weekly. Method of measurement: visual analogue of craving score.;Measuring the severity of dependency. Timepoint: At the onset of the study and then weeks 6th and 12th. Method of measurement: Dependency severity index.;Measuring the severity of depression. Timepoint: At the onset of the study and then weeks 6th and 12th. Method of measurement: Beck’s Depression Inventory.;Measuring the aggression severity. Timepoint: At the onset of the study and then weeks 6th and 12th. Method of measurement: Aggressive questionnaire (AGQ).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Adibi

Medical College

amir771155@yahoo.com+98 54 3351 3777

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026