Effectiveness of vitamin B and E in reducing pain

Comparing the effectiveness of vitamin B and E with diclofenac in reducing pain from osteoarthritis of the knee

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201408306480N7

Enrollment

120

Registered

2014-10-03

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee. Arthrosis, unspecified

Interventions

Intervention 1: Oral diclofenac 50 mg , 2 times daily and vitamin B complex tablets 2 times a day. Intervention 2: Oral diclofenac 50 mg 2 times a day, and vitamin E at a dose of 100 mg daily. Interv

Treatment - Drugs

Placebo

Oral diclofenac 50 mg , 2 times daily and vitamin B complex tablets 2 times a day

Oral diclofenac 50 mg 2 times a day, and vitamin E at a dose of 100 mg daily

Oral diclofenac 50 mg 2 times a day plus a placebo pill

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria included : having 30 to 60 years of age, a diagnosis of primary osteoarthritis of the knee by an orthopedic doctor( based on history, clinical signs, physical examination, and radiographic diagnosis of the disease and diagnostic criteria related to this disease) . Exclusion criteria included : secondary osteoarthritis, infection or inflammatory disease of the knee joint, crystal-induced arthritis, tumors, intra-articular, knee ligament instability, previous fracture, intra-articular, knee surgery (arthroscopic or other in the past 12 months, an intra-articular injection, visual analog score less than 3 on the knee therapy in the treatment , severe concurrent disorders such as metabolic disorders and a history of certain diseases, including stroke in the past, uncontrolled hypertension, gastritis, infectious diseases, kidney failure, stomach ulcers, allergies to medications (vitamin B complex, vitamin E, vitamin B and E and the other contradictions receptor of vitamin E and B

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Morning stiffness. Timepoint: Intervention, two weeks and three weeks later. Method of measurement: Western Ontario MacMaster questionnaire.;Pain. Timepoint: Intervention, two weeks and three weeks later. Method of measurement: Visual analog scale (VAS).;Physical function. Timepoint: Intervention, two weeks and three weeks later. Method of measurement: Western Ontario MacMaster questionnaire.	—

Secondary

Measure	Time frame
Consent to treatment. Timepoint: Three weeks after treatment. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Morteza Dehghan

Shahrekord University of Medical Sciences

dehghan_mortaza@yahoo.com+98 38 1333 0061

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026