Epilepsy. Generalized idiopathic epilepsy and epileptic syndromes
Conditions
Interventions
Intervention 1: case group will be treated with 250 mg LEV tablet and the drug dose will be increased until the patient will be seizure free. The maximum dose of LEV is 2500mg daily. Intervention 2: T
Treatment - Drugs
case group will be treated with 250 mg LEV tablet and the drug dose will be increased until the patient will be seizure free. The maximum dose of LEV is 2500mg daily.
The control group will be treated with 10-15 mg/kg sodium valporate and the drug dose will be increased until the patient will be seizure free. The maximum dose of sodium valporate is 30-60 mg/kg.
Sponsors
Deputy for research affairs of Shahrekord University of Medical Scince
Eligibility
Sex/Gender
All
Age
8 Years to 25 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria included patients how have JME (Juvenile Myoclonic epilepsy ) with two myoclonus and no EEG changes; or a Myoclonus with EEG changes, which this changes include specific changes (3-6Hz spike / polyspike slow wave discharge); epilepsy should start at 8 to 25 years old. The exclusion criteria included, neurological disorders; mental disorder; history of pseudoseizures; history of mental or mood disorder; the use of drugs affecting the central nervous system in a month before beginning of the study; metabolic disorders; infectious disease; malignancy; pregnancy and disease that their treatment interact with valproate sodium or Leveteracetam.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electro encephalo gram (EEG) changes. Timepoint: Before, 3 mounths and 6 mounths after inital treatment. Method of measurement: Electro encephalo gram (EEG) that is taken by EEG machine. This changes contains 3-6 Hz Bilateral spike/polyspike slow wave discharge.;Count of seizures after treatment. Timepoint: After ending the period of treating (6 mounths after initial treatment). Method of measurement: According to patients and thier fellows history.;Count of myoclonus after treatment. Timepoint: 3 and 6 mounths after initial treatment. Method of measurement: According to patients and thier fellows history. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sodium valporate side effects, that contains Asthenia, Headache, Smnolence, Cough, Nervousness, Amnesia, Ataxia, Depression, Nuasea, Vomiting, Tremor, Alopesia, Diziness, Dyspepsia, Rash, Weight Gain, Increase or decrease of appetite. Timepoint: 3 and 6 mounths after initial treatment. Method of measurement: According to asking from patient and chek list.;Leveteracetam side effects that contains Asthenia, Headache, Smnolence, Cough, Nervousness, Amnesia, Ataxia, Depression, Nuasea, Vomiting, Tremor, Alopesia, Diziness, Dyspepsia, Rash, Weight Gain, Increase or decrease of appetite. Timepoint: 3 and 6 mounths after initial treatment. Method of measurement: According to asking from patient and chek list. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Jafar Mehvari
Isfahan University of Medical Scince
Outcome results
None listed