Major depression. Depressive episode
Conditions
Interventions
Intervention 1: Folic acid tablet, one half of 5 mg tablets, once per day for 8 weeks. Intervention 2: Tablets without the active ingredient with the same size and shape of Folic acid tablet, a half t
Treatment - Drugs
Placebo
Folic acid tablet, one half of 5 mg tablets, once per day for 8 weeks
Tablets without the active ingredient with the same size and shape of Folic acid tablet, a half tablet daily, for 8 weeks
Sponsors
Vice Chancellor for research, Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: To have a definite diagnosis of major depressive disorder according to the DSM-IV-TR criteria; Being between 20 and 50 years old; To get the minimum score of 12 from the BDI 2 scoring system; Having stopped taking any other antidepressant medications since 4 weeks before starting folic acid; Patients who sign the written informed consent after being provided with the detailed information about the study; Not having anemia based on a Complete Blood Count (CBC) test; The absence of pregnancy; No alcohol or substance use in 6 months prior to the study; The absence of manic episodes; The absence of psychotic symptoms; The absence of mental retardation; Depression not due to a general medical condition or substance; The absence of any severe or chronic physical illnesses. Exclusion criteria: Having any acute and severe medical conditions; The incidence of any severe psychiatric disorders (suicidal thoughts, psychotic symptoms, manic phase symptoms, etc.); Failure to follow-up for at least 4 weeks; The concomitant use of other psychotropic drugs; The incidence of severe complications during treatment.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression severity. Timepoint: 4, 6 and 8 weeks after starting the treatment. Method of measurement: The Beck Depression Inventory 2nd Edition. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Narges Gholampour
Kashan University of Medical Sciences
Outcome results
None listed