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The effect of captopril on definitive patients with coronavirus pneumonia

Evaluation the effect of captopril on definitive patients with COVID-19(second phase)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20140824018915N10
Enrollment
400
Registered
2021-09-23
Start date
2021-09-21
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronavirus pneumonia. This code assigned to a disease diagnosis of COVID-19 confirmed by laboratory testing

Interventions

Intervention 1: Intervention group: In addition to the usual treatment regimen, patients receive captopril at a dose of one 25 mg tablet every 8 hours for 2 weeks from the start of treatment (Without

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: COVID-19 disease confirmed by imaging (HRCT) or Real Time PCR

Exclusion criteria

Exclusion criteria: Pregnancy Breastfeeding Bilateral renal artery stenosis Hereditary angioedema Psoriasis NSAID consumtion Patients who have been taking Captopril before undergoing Covid due to other underlying diseases (such as hypertension, heart failure, myocardial infarction, etc.) will not be included in the study. Patients in need of ICU admission The patient participates in any other clinical trial on the corpus associated with therapeutic intervention. (Before entering this study)

Design outcomes

Primary

MeasureTime frame
Percentage of oxygen secretion. Timepoint: At the beginning of the study (before the intervention) and 14 days after the start of taking captopril. Method of measurement: Using a pulse oximeter.;Mortality rate. Timepoint: At the end of hospitalization of patients. Method of measurement: According to the physician report.;Duration of hospitalization. Timepoint: At the end of hospitalization of patients. Method of measurement: According to the physician report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMousalreza Hoseini

Mashhad University of Medical Sciences

hoseinimr@mums.ac.ir+98 51 3801 2742

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026