ovarian cysts. Other and unspecified ovarian cysts
Conditions
Interventions
Intervention 1: Intervention group: Metformin 500 mg ,oral tablets, three times a day for 6 months. Intervention 2: Control group: participants in the control group will take three placebo tablets dai
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Adjutant treatment of breast cancer with tamoxifen Normal pelvic exam Performance state 0-2
Exclusion criteria
Exclusion criteria: Serious diseases, heart or endocrine or other systemic diseases Use of systemic hormone therapy during past 6 months Alcohol consumption Diabetes Advanced breast cancer Having any cancer or malignancy other than breast cancer during the last three years Atypical hypoplasia or endometrial cancer abnormal ovarian cysts with the possibility of malignancy on ultrasound Contraindications for using metformin (eg: allergy to biguanides, acidosis, heart disease, alcohol consumption, gastroparesis, liver disease, hyperthyroidism or hypothyroidism, severe iron deficiency anemia, renal impairment) Unbearable and dangerous side effects of metformin (such as: abdominal pain, chest pain, chills, cholestasis, severe diarrhea, dizziness, increased liver enzymes, severe headache, hepatitis, hypoglycemia, megaloblastic anemia, myalgia, palpitations, Skin rash and rash, vomiting)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometrial thickness. Timepoint: Before and after treatment. Method of measurement: Vaginal ultrasoun.;Number and characteristic of ovarian cyst. Timepoint: Before and after treatment. Method of measurement: Vaginal ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in liver enzymes. Timepoint: Before and after treatment. Method of measurement: laboratory test.;Chenges in weight. Timepoint: Before and after treatment. Method of measurement: Scales.;Changes in weight. Timepoint: Before and after treatment. Method of measurement: Laboratory test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfsaneh Tehranian
Tehran University of Medical Sciences
Outcome results
None listed