Nasal polyp. Nasal polyp
Conditions
Interventions
In both group oral aspirin challenge test is done. On the first day,aspirin with exponentially increasing doses (20,40,80mg),are administered at 3-hour intervals and On the second day,aspirin with e
Diagnosis
Sponsors
Guilan University of Medical Sciences,Vice Chancellor for Research
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:All patients with nasal polyps that including male and female and in range of 18-60 years old who referred to ENT service in Rasht, Amiralmomenin hospital and diagnosis of nasal polyps is definite for them by endoscopy or CTs if don't have contraindications for oral aspirin challenge test inclusion to our study. Those with contraindications for oral aspirin challenge test were left out of the study : 1-a history of very severe anaphylactic reaction, 2-severe disease of the heart, digestive tract, liver and kidney, 3- infection of respiratory tract within 4weeks prior to the challenges, 4- pregnancy, 5- current treatment with beta receptor blocker. Control group is healthy people that don't have nasal polyps and contraindications for oral aspirin challenge test. Exclusion criteria:If the result of test is positive.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasoocular symptoms alone. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection.;Nasoocular symptoms and a 15% or greater decline in FEV(classic reaction). Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam.;Lower respiratory reaction only (FEV1 declines by >20%). Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam.;Laryngospasm with or without any of the first 3 reactions. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam.;Systemic reactions: hives, flushing, gastric pain, hypotension. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Shadman Nemati
Guilan University of Medical Sciences
Outcome results
None listed