Condition 1: Hepatitis B vaccine. Condition 2: Bone marrow transplant. viral vaccine
Conditions
Interventions
Intervention 1: Intervention group:Patients in the intervention group will receive hepatitis B vaccinations, six months after transplantation, provided they are not receiving immunosuppressive medica
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 65 years old Participants must have undergone either allogeneic or autologous bone marrow transplantation. At least 6 months must have passed since the date of transplantation. Hepatitis Test Results: Participants must have negative HBs Ag and HBC Ab titers.
Exclusion criteria
Exclusion criteria: Use of immunosuppressive medication Active GVHD grade 3 and 4 History of chronic hepatitis B Prophylactic treatment with tenofovir due to positive HBc Ab Lack of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-HBs seroconversion. Timepoint: Before the administration of the first dose of the vaccine, three weeks after the first dose, and one to two months after the third dose. Method of measurement: blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLeyla Sharifi Aliabadi
Tehran University of Medical Sciences
Outcome results
None listed