knee arthrosis. Primary osteoarthritis of other joints
Conditions
Interventions
Intervention 1: Intervention Group: For this purpose, 140 patients with OA, with an average age of 40 years, will be selected. To inject mesenchymal cells, the following steps are performed: puncturin
Sponsors
Motamed Cancer Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Symptomatic OA knee: This includes individuals who experience daily pain that has started at least3 months prior to their visit. Patients should fall within grades1-3 of the Lawrence-Kellgren criteria. (The reason for using this range of grades in the Lawrence-Kellgren classification is that similar studies in cell therapy mostly begin with mild stages. This is because the application of cell therapy in diseases shows increased accuracy, as in advanced stages of the disease, the likelihood of minor effectiveness being overlooked is very high due to the progression of disease severity.) Radiographic changes in the specified knee should be observed without meniscus tears.
Exclusion criteria
Exclusion criteria: Generalized bone marrow edema in the condyle or tibia on MRI Moris deformity (varus or valgus) more than10 Hyaluronic acid use in the knee during the past6 months Intra-articular steroid use in the past6 months Oral steroid use in the past3 months Simultaneous pain in the ankle or hip on the same side Local or systemic infection Any manifestation of secondary arthritis Recent history of malignancy BMI greater than30 Autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain reduction score in the questionnaire. Timepoint: Multiple time intervals of 1, 3, 6, 9, and 12 weeks after the intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index and Visual Analogue Scale.;Evaluation of cartilage thickness and health in different parts of the knee. Timepoint: 12 months after the intervention. Method of measurement: Magnetic resonance imaging(MRI). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Ghenaati
Tehran University of Medical Sciences
Outcome results
None listed