Neuroblastoma. Malignant neoplasm of unspecified part of unspecified adrenal gland
Conditions
Interventions
Intervention group:The patient will receive cyclophosphamide 60 mg/kg on day -3 and day -2 prior to the NK cell infusion for lymphodepletion.Haploidentical donor NK cells will be expanded over 10 days
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 25 Years
Inclusion criteria
Inclusion criteria: Harvesting and stem cell cryopreservation should be done before admission for HSCT. Patients should be in complete remission. Patients must have adequate organ function including hematologic, cardiac, renal, respiratory and liver. Karnofsky or Lansky performance score of greater than or equal to 50. Patient has a suitable adult family member donor available for NK cell donation. At least two weeks since receipt of any biological therapy, systemic chemotherapy, and/or radiation therapy. 1-25 y/o patients with neuroblastoma candidate for auto-hsct
Exclusion criteria
Exclusion criteria: Active or uncontrolled infection Patient declines participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overal survival. Timepoint: 1 year. Method of measurement: CTscan. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTahereh Rostami
Tehran University of Medical Sciences
Outcome results
None listed