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Effect of phenytoin mucoadhesive paste 1% on periodontal parameters

Evaluation of effect of phenytoin mucoadhesive paste 1% after non-surgical therapy on improvement of periodontal status in moderate to severe chronic periodontitis patients

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014081718834N1
Enrollment
20
Registered
2015-02-07
Start date
2015-01-30
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: In control side after the first phase of periodontal treatment was accomplished which including oral hygiene instructions, scaling and root planning, instructions about the application
Placebo
Treatment - Drugs
In control side after the first phase of periodontal treatment was accomplished which including oral hygiene instructions, scaling and root planning, instructions about the application of the paste wa
After the first phase of periodontal treatment was accomplished which including oral hygiene instructions, scaling and root planning, instructions about the application of the paste was given to all p

Sponsors

Vice chancellor for research of Shahid Sadoughi Dental Faculty
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria were considered as follows: having ability to read and write, no systemic diseases such as diabetes or heart disease, not taking medications affecting periodontium (anti- hypertensives, immune suppressants and anticonvulsants), not being pregnant, no smoking, no traumatic occlusion, no history of antibiotic therapy within the last three months, having at least two similar teeth on each sextants without any decays or restorations and filling informed consent form. In addition we consulted with internist about any drug interactions to phenytoin in patients of our study. The exclusion criteria were considered as follows: 1) inappropriate control plaque during the study. 2) irregular use of pastes on the basis of given instructions 3) not taking part in following up appointments.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pocket depth. Timepoint: 4 weeeks. Method of measurement: milimeters by Williams’s periodontal probe.;Bleeding on probing. Timepoint: 4 weeks. Method of measurement: percentage.;Modified gingival index. Timepoint: 4 weeks. Method of measurement: grading by observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Nahid Nasrabadi

Dental school of Yazd

nasrabadi.nahid@gmail.com+98 35 1621 2623

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026