comparison of ovulation induction with different gonodotropins

Comparison of effect of four different protocols for ovarian stimulation including: hFSH, rFSH, HMG, sequential use of hFSH & rFSH on quality of oocyte and embryo

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201408116541N7

Enrollment

160

Registered

2014-09-16

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unexplained infertility and male infertility. female infertility, unspecified

Interventions

Intervention 1: The first group(40 pt) received HP-HMG (menopur, ferring pharmaceuticals, Copenhagen Denmark) from day 2 to the hCG day. Intervention 2: The second group(40 pt) received hFSH (Fosti

Treatment - Drugs

The first group(40 pt) received HP-HMG (menopur, ferring pharmaceuticals, Copenhagen Denmark) from day 2 to the hCG day.

The second group(40 pt) received hFSH (Fostimon, IBSA, Geneva, Switzerland) from day 2 to the hCG day.

The third group(40 pt) received rFSH (Gonal-F, Sereno, Rome, Italy) from day 2 to the hCG day

- The fourth group(40 pt) received hFSH (Fostimon, IBSA, Geneva, Switzerland) for six days and then continued with rFSH (Gonal-F, Sereno, Rome, Italy) to the hCG day

Eligibility

Sex/Gender

Female

Age

No minimum to 39 Years

Inclusion criteria

Inclusion criteria: Exclusion criteria: Unexplained infertility? Male infertility Inclusion criteria: Ovarian disease? Previous failure of ovulation induction with FSH Age more than 40 years old? FSH more than 10mIU/ml? AFC less than 5 in both ovaries? AMH less than 1ng/ml

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
- quality and number of ovum and emberyo have received in each cycle. Timepoint: - On the day of oocyte retrieval, three days after oocyte fertilization. Method of measurement: Measuring number and quality of oocytes on the day of pick up in lab by an embryologist under microscope (GV , MI , MII ) and quality of emberyo also by the same embryologist due to kind of cell division ( Grade I , II , III , IV).	—

Measure

Time frame

- quality and number of ovum and emberyo have received in each cycle. Timepoint: - On the day of oocyte retrieval, three days after oocyte fertilization. Method of measurement: Measuring number and quality of oocytes on the day of pick up in lab by an embryologist under microscope (GV , MI , MII ) and quality of emberyo also by the same embryologist due to kind of cell division ( Grade I , II , III , IV).

—

Secondary

Measure	Time frame
- Biochemical pregnancy, clinical pregnancy. Timepoint: - 12 days after embryo transfer, 6 weeks after embryo transfer. Method of measurement: ßhCG titer, detecting gestational sac by sonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr solmaz rezaei

shiraz University of Medical Sciences

solmaz_rz@yahoo.coms.kharati@yahoo.com+98 71 1227 9715

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026