Effects of interval exercise training on MirRNA levels in breast cancer

Impact of an interval exercise with drug therapy involving Tamoxifen and Letrozol on serum microRNAs level in women with non-metastatic breast cancer: Randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014081018745N1

Enrollment

Registered

2014-09-07

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer. Breast, unspecified

Interventions

Intervention 1: Exercise group: Exercise protocol includes (1) measurement of blood pressure and heart rate, (2) warm up for 10-15 minutes, which includes gentle movements, stretching and range of mo

Treatment - Other

Exercise group: Exercise protocol includes (1) measurement of blood pressure and heart rate, (2) warm up for 10-15 minutes, which includes gentle movements, stretching and range of motion movement, (

Control group: The control group will not receive any exercise protocol.

Eligibility

Sex/Gender

Female

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Randomize; obtaining informed consent; patients with non-metastatic disease (level 1 to 3); completed treatment with chemotherapy and radiotherapy (at least one month); patients with estrogen and progesterone receptors. Exclusion criteria: patients with tobacco and alcohol consumption; patients with unwillingness to exercise; patients with serious acute and chronic heart failure; patients with serious chronic respiratory failure; patients with chronic liver failure; patients with metastatic disease to bone and brain.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum level of miR-21. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-222. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-155. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-let7. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-143. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-145. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-206. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-221. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-200. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.	—

Measure

Time frame

Serum level of miR-21. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-222. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-155. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-let7. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-143. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-145. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-206. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-221. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.;Serum level of miR-200. Timepoint: Before and after of exercise. Method of measurement: QPCR-Real Ttime.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ali Mohammad Alizadeh

Tehran University of Medical Sciences

aalizadeh@razi.tums.ac.ir+98 21 6119 2501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026