Evaluation of the effect of isotretinoin on the serum level of homocystein with and without folic acid and vit B12 intake

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014081018607N1

Enrollment

Registered

2015-06-29

Start date

2015-07-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne. Acne vulgaris

Interventions

Intervention 1: Intervention group: Vitamin B12, Amp 1 gram, intramuscular injection,once a month for 2 months. Intervention 2: Intervention group: Folic acid, Tab 1 miligram,oral, once a day for 2 m

Treatment - Drugs

Intervention group: Vitamin B12, Amp 1 gram, intramuscular injection,once a month for 2 months

Intervention group: Folic acid, Tab 1 miligram,oral, once a day for 2 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Acne patients over 18 years of age who have indication of isotretinoin therapy Exlusion criteria: pregnancy; lactation; hyperlipidemia; liver failure; renal failure; diadetes mellitus; hypertension; thyroid dysfunction; psoriasis; Behcet disease; intake of antibiotics of cyclin group; smoking; alcohol use; genetic disorders of aminoacids metabolism; multivitamin or folic acid or vit B12 intake

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum homocysteine level. Timepoint: before and 2 months after treatment. Method of measurement: measurement in laboratory.	—

Secondary

Measure	Time frame
Serum vitamin B12 level. Timepoint: before and 2 months after treatment. Method of measurement: measurement in laboratory.;Serum folic acid level. Timepoint: Before and 2 months after treatment. Method of measurement: Measurement in laboratory.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Ghiasi

Tehran University of Medical Sciences, Departement of Dermatology

mghiasi@tums.ac.ir+98 21 5561 8989

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026