Effect of Oxygen on results of corneal cross linking

Evaluation of safety and efficacy of higher concentrations of Oxygen in corneal collagen cross linking for progressive keratoconus patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140808018729N2

Enrollment

Registered

2020-04-29

Start date

2017-10-23

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus. Keratoconus, unspecified, unspecified eye

Interventions

Intervention 1: Intervention group: In the experimental group (20 eyes), the concentration of oxygen in the environment will be increased to 50-60% (by placing the patient's head into a special chamb

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: progressive KCN Mild to moderate KCN (Kmax< 58D) Signing informed consent form

Exclusion criteria

Exclusion criteria: Any other ocular comorbidity Corneal thickness<450 micron

Design outcomes

Primary

Measure	Time frame
Keratometric and topographic corneal changes. Timepoint: 0, 1, 3, 6, 12 months. Method of measurement: Refraction, pentacam, Confocal, OCT.;Pain. Timepoint: Intra operative. Method of measurement: Visual analogue scale.;Complications. Timepoint: through the course of study. Method of measurement: examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHaider Abbas

Tehran University of Medical Sciences

hider87@gmail.com+98 21 5541 0005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026