Cognitive disorders. Other and unspecified symptoms and signs involving cognitive functions and awareness
Conditions
Interventions
Intervention 1: Participants in case group will receive 30 mg Saffron/day orally (as two 15 mg capsules of Saffron). Saffron will be given to them from 3 days before surgery to 3 months after that. In
Treatment - Drugs
Placebo
Participants in case group will receive 30 mg Saffron/day orally (as two 15 mg capsules of Saffron). Saffron will be given to them from 3 days before surgery to 3 months after that.
Participants in control group will receive 30 mg placebo/day (as two capsules of 15 mg placebo). Placebo will be given to them from 3 days before surgery to 3 months after that. The shape, size and c
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age between 30 to 70 year-old. Patients who undergo on-pump cardiac surgery. Patients who have more than 70 in Wechsler memory scale. Exclusion criteria: Patients who do not give informed consent. Patients who undergo off-pump cardiac surgery. Patients who undergo valvular surgery. Patients who are on Warfarin. Patients with severe arrhythmia. Patients who have hypersensitivity to Saffron.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wechsler memory scale score. Timepoint: Before intervention, one week after surgery, and three months after surgery. Method of measurement: Scores of Wechsler memory scale will be compared. | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium. Timepoint: After intervention and during hospitalization. Method of measurement: Standard Delirium Rating Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Seyed Hesameddin Abbasi
Tehran Heart Center
Outcome results
None listed