Effects of tumeric and Serrapeptase capsule on reducing pain and improve range of motion in patients with osteoarthritis of the knee

Effects of tumeric (Curcuma longa) and Serrapeptase supplementation on reducing pain and improve range of motion in patients with osteoarthritis of the knee ( a double blind randomized controlled trial)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140804018677N8

Enrollment

Registered

2021-03-02

Start date

2021-02-28

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Serapeptase (30 mg)/turmeric (20 mg) per cap- for 10 days- rayan pharmed company. Intervention 2: Control group: placebo containing maltodextrine-for 10 days- rayan

Eligibility

Sex/Gender

All

Age

45 Years to No maximum

Inclusion criteria

Inclusion criteria: age>45y and having knee osteoarthritis according to American College of Rheumatology diagnostic criteria Knee pain with at least three of the followings: age>50, morning stiffness<30 min, crepitation, bone tenderness at knee, knee bone enlargement, warmness or pain in addition to osteophyte according to radiography Grade 2 or 3 of osteoarthritis according to Kellgren and Lawrence system Pain intensity between 5-8 at baseline according to Visual analog scale-VAS Able to walk independently

Exclusion criteria

Exclusion criteria: not having joint arteritis, orthopedic or severe cardiovascular diseases intra-articular injection of corticosteroids in past 3 months, as well as gel, and Platelet-rich plasma (PRP) in past year Severe pain or allergic reaction during intervention that need for Nonsteroidal anti-inflammatory drugs (NSAIDs) unable to complete the study BMI>35

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Baseline and at the end of the study. Method of measurement: VAS (visual analog scale).;Range of Motion and stiffness. Timepoint: Baseline and at the end of the study. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoodeh Razeghi Jahromi

Shahid Beheshti University of Medical Sciences

soodehrazeghi@gmail.com+98 21 2235 7483

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026