osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: Patients will be asked to gently rub a thin layer of gel containing 0.3% serapeptase and 0.3% bromolin every 4 hours for 10 days. Intervention 2: Control group: Pat
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: age>45y and having knee osteoarthritis according to American College of Rheumatology diagnostic criteria Knee pain with at least three of the followings: age>50, morning stiffness<30 min, crepitation, bone tenderness at knee, knee bone enlargement, warmness or pain in addition to osteophyte according to radiography Grade 2 or 3 of osteoarthritis according to Kellgren and Lawrence system Pain intensity between 5-8 at baseline according to VAS Able to walk independently
Exclusion criteria
Exclusion criteria: having joint arteritis, orthopedic or severe cardiovascular diseases having intra-articular injection of corticosteroids in past 3 months, as well as gel, and Platelet-rich plasma (PRP) in past year having allergic reaction to tumeric and Serrapeptase
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: Baseline and at the end of the study. Method of measurement: VAS (visual analog scale).;Range of Motion and stiffness. Timepoint: Baseline and at the end of the study. Method of measurement: WOMAC. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSoodeh Razeghi Jahromi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed