Efficacy of Fractional CO2 laser with or without punch elevation for treatment of depressed acne scars

Comparison of the efficacy of ablative fractional CO2 laser combined with punch elevation vs ablative fractional CO2 laser alone in treatment of depressed acne scar.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014080218647N1

Enrollment

Registered

2014-09-29

Start date

2014-05-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acne scar. Scar conditions and fibrosis of skin

Interventions

Intervention 1: In one side of the face, 24 hours before the first session of laser treatment, punch elevation is done, followed by a session of Fractional CO2 ablative (Q ray, Diosis Inc, Seoul, Kore

Treatment - Devices

In one side of the face, 24 hours before the first session of laser treatment, punch elevation is done, followed by a session of Fractional CO2 ablative (Q ray, Diosis Inc, Seoul, Korea) with pulse en

On the other side of the face, without punch elevation (control group) a session of Fractional CO2 ablative (Q ray, Diosis Inc, Seoul, Korea) with pulse energy: 25 mj per fixed150 µm diameter microbea

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age =18 years; patient suffering from polymorphic and mixed acne scars; Fitzpatrick skin types2 to4; informed consent for participation. Exclusion Criteria: Presence of hypertrophic or Keloid scars; patient not returning for follow up visits; patient discontinuing intervention; suspect pregnancy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Atrophic scar of acne. Timepoint: One and four months after the first laser therapy session. Method of measurement: by two independent dermatologists blinded to the randomization.	—

Secondary

Measure	Time frame
Edema; Erythema; Pruritis; Hypo and Hyper pigmentation. Timepoint: After three days, one week, one month and four months the first laser therapy session. Method of measurement: Patient self administered checklist of overall satisfaction.;Clinical improvement of atrophic scar. Timepoint: One and four months after the first laser therapy session. Method of measurement: Patient self administered checklist of overall satisfaction.;Patients satisfaction. Timepoint: One and four months after the first laser therapy session. Method of measurement: Visual Analog Score.	—

Measure

Time frame

Edema; Erythema; Pruritis; Hypo and Hyper pigmentation. Timepoint: After three days, one week, one month and four months the first laser therapy session. Method of measurement: Patient self administered checklist of overall satisfaction.;Clinical improvement of atrophic scar. Timepoint: One and four months after the first laser therapy session. Method of measurement: Patient self administered checklist of overall satisfaction.;Patients satisfaction. Timepoint: One and four months after the first laser therapy session. Method of measurement: Visual Analog Score.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Saeid Nouraei

Skin disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Ira

saeidnouraei@resident.mui.ac.ir+98 31 3628 9194

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026