Septic shock. Septic shock
Conditions
Interventions
Intervention 1: Hydrocortisone administration every 6 hours for 7 days in intervention group. Intervention 2: Placebo (normal saline solution 0.9%) administration every 6 hours for 7 days in control g
Treatment - Drugs
Placebo
Hydrocortisone administration every 6 hours for 7 days in intervention group
Placebo (normal saline solution 0.9%) administration every 6 hours for 7 days in control group
Sponsors
Mashhad University of medical Siences
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: All patients above eighteen who admitted in Imam Reza Hospital of Mashad with diagnosis of septic shock and do not respond to vasopressor therapy more than 60 minutes are included. Those who suffer from adrenal insufficiency before admission or had tuberculosis or had been treated with ketoconazole or estrogens are excluded. Those with no consent with the plan are also excluded
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality in 28 days. Timepoint: During 28 days. Method of measurement: Death records. | — |
Secondary
| Measure | Time frame |
|---|---|
| Response to vasopressor. Timepoint: The time that there is no need to vasopressor. Method of measurement: Normal central vein pressure (6-12 Cm H2O), mean arterial pressure more than 65 mmHg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Azadeh Mahmoudi Gharaee
Mashhad University of Medical Sciences
Outcome results
None listed