The effect of N-acetyl cysteine and vitamin C on kidney in patients undergoing open heart surgery.

Comparison of protective effects of N-acetyl cysteine and vitamin C on perioperative renal function in high-risk patients undergoing cardiac bypass surgery.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014072815102N4

Enrollment

Registered

2014-08-22

Start date

2014-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Renal failure. Condition 2: coronary vessel disease. Acute renal failure Atherosclerosis heart disease

Interventions

Intervention 1: Intervention1: Acetyl cysteine (EXI-NACE, EXIR pharmaceuticals, Borujerd, Iran), 2gr/lit injectable ampule, 3ml, 4doses within 24 hours after surgery. Intervention 2: Intervention 2: p

Treatment - Drugs

Intervention1: Acetyl cysteine (EXI-NACE, EXIR pharmaceuticals, Borujerd, Iran), 2gr/lit injectable ampule, 3ml, 4doses within 24 hours after surgery.

Intervention 2: placebo, 2gr/lit injectable ampule, 3ml, 4doses within 24 hours after surgery.

intervention3: vitamin C ( OSVE-VITAMIN C, Osve pharmaceuticals, Tehran, Iran), 500mg/5ml injectable ampule, 30 ml, 4 doses within 24 hours after surgery

Eligibility

Sex/Gender

All

Age

70 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age above 70 years old; Renal failure; Serum Cr level above 1.4 mg/dl; Heart ejection fraction of below 35%; Concomitant valve surgery with bypass surgery; History of previous coronary artery surgeries; Diabetes under treatment with oral agents or insulin. Exclusion criteria: The emergency cardiac bypass surgery; History of heart transplantation; Acute renal failure; Serum Cr level higher than 4.5 mg/dl; History of renal transplantation; N-acetyl cysteine consumption in the last 5 days prior to the operation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The effect of N-acetyl cysteine on kidney. Timepoint: the 1st, 2nd and 3rd day after surgery. Method of measurement: Serum creatinine level.;The effect of N-acetyl cysteine and vitamin C on kidney. Timepoint: the 1st, 2nd and 3rd day after surgery. Method of measurement: Serum creatinine levels.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: before surgery. Method of measurement: the peripheral blood pressure was measured with sphygmomanometer.;Number of grafts. Timepoint: after surgery. Method of measurement: review of operation note.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeed Reza Soltani

Department of Anesthesiology and Student Research Committee

saeedrezasoltani@gmail.com+98 71 1634 1256

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026